by vyapada on Wed Jul 04, 2007 1:39 pm
I honestly don't have any explanation off the top of my head as to the etiology. As you said, muscle breakdown markers weren't found in the study - so this seems to be out.
I'd like to say that my understanding of 'central fatigue' distinguishes 'central fatigue' from 'neural fatigue' as peripherally, excitation contraction coupling or autonomic nervous system (the sympathetic system is mentioned) may be play a role and it may not be related to muscle damage or activity in the motor cortex.
There may well be a neural explanation for this fatigue - if you could provide an explanation for the long term effects (~8 wks as cited) then I would be most grateful.
Perhaps protein accretion or another metabolic system is involved?